Sodium Chloride → HCID 59294620, compound

Participants

Reaction Conditions

Reaction Steps

Benzoyl chloride (0.15 g) was added to the aqueous solution of (R)-1-(p-methylbenzoyl)-3-aminopiperidine obtained in Example 13 (amount: 3 g), and the pH of the mixture was kept from 8.0 to 9.0 using sodium hydroxide. The mixture was stirred at 15° C. for 3 hours. Chlorobenzene (3 ml) and sodium chloride (0.5 g) were added thereto, and then the mixture was stirred at 90° C. for 10 minutes. The water layer was removed, and the solvent was evaporated under reduced pressure to obtain the title compound as yellow crystal (0.33 g, yield: 73%).

Provenance & Evidence