反应详情

2.75 g (10.2 mmol) of 3-ethoxycarbonyl-6-chloro-7-hydroxycoumarin was added into 10 ml of concentrated sulfuric acid, 1.74 g (20.4 mmol) of concentrated nitric acid was added in portions under the cooling of ice-salt bath, the reaction was monitored through thin-layer chromatography to confirm the completion, and ice was added to seize the reaction. The reaction mixture was then filtered and washed by water, dried to give 1.52 g of the title compound (241).

1. additionwas added in portions under the
2. temperaturecooling of ice-salt bath
3. additionwas added
4. customthe reaction
5. filtrationThe reaction mixture was then filtered
6. washwashed by water
7. customdried