HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-nitro-5-piperazin-1-yl-benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 5-Chloro-2-nitrobenzoic acid | HCID 17286 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-nitro-5-piperazin-1-yl-benzoic Acid | HCID 10562687 | 99.5% |
Reaction Steps
To the suspension of 50 g 2-nitro-5-chlorobenzoic acid in 750 ml water, 86 g of piperazine is added and the reaction mixture is heated at reflux temperature for 20 hours. The mixture is then neutralized with conc. hydrochloric acid and the precipitated crystalline material is filtered off and dried to obtain 62 g title compound (MH+: 252)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338411B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-849456b97daf4633bb5ea947dff32749 |
| Source note | uspto-grants-2012_12 |