HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-amino-2,3-dihydro-1H-indol-1-yl)ethan-1-one → 1-Acetylindoline-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-amino-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 292507 | — |
| Reactant | 1-Acetylindoline-5-carbonitrile | HCID 18526421 | — |
| Product | 1-Acetylindoline-6-carbonitrile | HCID 67317991 | — |
Reaction Steps
The title compound was prepared following the procedure described for 1-acetoylindoline-5-carbonitrile but starting from 1-(5-aminoindolin-1-yl)ethanone (Aldrich, 844 mg; 4.79 mmol), to give 1-acetoylindoline-6-carbonitrile as an orange solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.31 (1H, s), 7.52-7.45 (2H, m), 4.18 (2H, t, J=8.6 Hz), 3.32-3.23 (2H, m), 2.23 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202856B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-06532395c5884f73a9e0f81f462d5f9b |
| Source note | uspto-grants-2012_06 |