HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester → 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester | HCID 69448997 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester | HCID 69447499 | 92% |
Reaction Steps
A mixture of 1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester (0.23 g, 0.71 mmol), Pd (10% on carbon, 30 mg) and methanol (5 mL) was stirred under a hydrogen atmosphere (ballon) for 6 hr. The catalyst was removed by filtration and the solvents removed in vacuo to provide of 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester (0.19 g, 92% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338416B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ec5e7c88a7fb43b7a4a0079a49dee3b4 |
| Source note | uspto-grants-2012_12 |