Dimethylformamide → HCID 135887174, compound

Participants

Reaction Conditions

Reaction Steps

5-(3,4-Diamino-phenyl)-furan-2-carboxylic acid ((S)-cyclohexyl-methylcarbamoyl-methyl)-amide (25 mg, 67 mmol), 1,3-dimethyl-1H-pyrazole-4-carbaldehyde (9.2 mg, 74 mmol), and sodium bisulfite (7.73 mg, 74 mmol) are dissolved in DMF (1 mL) and the mixture is heated at 130° C. for 12 h. The mixture is filtered and purified on reversed phase (HPLC). The product is obtained as a beige solid. 4.2 mg, 13%, LC/MS ESI m/z (M+H)+=476.54.

Provenance & Evidence