HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 45376620, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66985358 | HCID 66985358 | — |
| Product | HCID 45376620 | HCID 45376620 | — |
Reaction Steps
To a solution of 6-{5-[((S)-cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-furan-2-yl}-1H-indole-2-carboxylic acid (20 mg, 0.047 mmol) is added subsequently HATU (10 mg, 0.052 mmol), DIEA (0.026 mL, 0.142 mmol), and morpholine (4.5 mg, 0.052 mmol). The reaction is stirred at room temperature for 2 h and is directly purified by reversed phase (HPLC). 7.0 mg, 30%, LC/MS ESI m/z (M+H)+=493.43.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338367B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-13a6a48cce234911ba6510665fcdff80 |
| Source note | uspto-grants-2012_12 |