HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethenyl-4-methylbenzene → 2-ethyl-2,3,4,5-tetrahydro-8-methyl-5-(4-methylphenethyl)-1H-pyrido[4,3-b]indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethenyl-4-methylbenzene | HCID 12161 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-ethyl-8-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | HCID 59455066 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-ethyl-2,3,4,5-tetrahydro-8-methyl-5-(4-methylphenethyl)-1H-pyrido[4,3-b]indole | HCID 57875976 | 9.8% |
Reaction Steps
The title compound was prepared according to General Method 2. 2-Ethyl-2,3,4,5-tetrahydro-8-methyl-5-(4-methylphenethyl)-1H-pyrido[4,3-b]indole was prepared from 2-ethyl-2,3,4,5-tetrahydro-8-methyl-1H-pyrido[4,3-b]indole (See Example 6) (100 mg, 0.4 mmol), 4-methylstyrene (1 mL, 7.6 mmol) and NaH (100 mg, 60% dispersion in oil, 2.5 mmol) in DMF (2 ml) at 180° C. for 24 h to obtain 13 mg of 2-ethyl-2,3,4,5-tetrahydro-8-methyl-5-(4-methylphenethyl)-1H-pyrido[4,3-b]indole after purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338408B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-8f2699c755be4c22ac530004b2166291 |
| Source note | uspto-grants-2012_12 |