Dimethylamine, hydrochloride → HCID 59604106, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example 94, but starting from 4-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde, obtained as described in Example 113, Step 1, (100 mg; 0.24 mmol) and dimethylamine hydrochloride (39.5 mg; 0.48 mmol) to give Example 131 as a white solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.62 (2H, dd, J=4.5, 1.7 Hz), 7.84 (2H, d, J=8.1 Hz), 7.78 (1H, td, J=7.6, 1.7 Hz), 7.63-7.56 (1H, m), 7.48 (2H, dd, J=4.5, 1.7 Hz), 7.42-7.35 (4H, m), 3.38 (2H, s), 2.08 (6H, s). LC/MS (Method C): 442 (M+H)+. HPLC (Method E) Rt 2.14 min (Purity: 94.2%).

Provenance & Evidence