4-Hydroxypyrrolidine → HCID 59604095, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example 94, starting from 3-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde (100 mg; 0.24 mmol) and 3-pyrrolidinol (32.7 mg; 0.48 mmol) to give Example 134 as an off-white solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.76-8.73 (2H, m), 7.97 (1H, s), 7.96-7.84 (2H, m), 7.76-7.69 (1H, m), 7.61 (2H, dd, J=4.5, 1.6 Hz), 7.59-7.49 (4H, m), 4.74 (1H, d, J=4.4 Hz), 4.29-4.21 (1H, m), 3.75-3.63 (2H, m), 2.75 (1H, dd, J=9.6, 6.2 Hz), 2.63 (1H, q, J=7.8 Hz), 2.51-2.45 (1H, m), 2.36 (1H, dd, J=9.6, 3.8 Hz), 2.10-1.99 (1H, m), 1.64-1.55 (1H, m). LC/MS (Method C): 484 (M+H)+. HPLC (Method E) Rt 2.13 min (Purity: 97.8%).

Provenance & Evidence