4-Acetamidopiperidine → HCID 59604054, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example 94, but starting from 4-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde, obtained as described in Example 113, Step 1, (100 mg; 0.24 mmol) and N-(piperidin-4-yl)acetamide (69 mg; 0.48 mmol) to give Example 137 as a white solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.76-8.73 (2H, m), 7.96 (2H, d, J=8.0 Hz), 7.94-7.88 (1H, m), 7.78-7.68 (2H, m), 7.61 (2H, dd, J=4.5, 1.6 Hz), 7.56-7.48 (4H, m), 3.56 (3H, m), 2.78 (2H, d, J=11.1 Hz), 2.06 (2H, t, J=11.3 Hz), 1.81 (3H, s), 1.73 (2H, d, J=12.3 Hz), 1.43 (2H, t, J=11.6 Hz). LC/MS (Method C): 539 (M+H)+. HPLC (Method E) Rt 2.13 min (Purity: 99.9%).

Provenance & Evidence