4-Piperidinemethanol → HCID 59604140, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example 94, but starting from 4-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde, obtained as described in Example 113, Step 1, (100 mg; 0.24 mmol) and 4-hydroxymethylpiperidine (55.9 mg; 0.48 mmol) to give Example 139 as a white solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.75 (2H, dd, J=4.48, 1.64 Hz), 7.97-7.86 (3H, m), 7.76-7.69 (1H, m), 7.61 (2H, dd, J=4.5, 1.7 Hz), 7.55-7.48 (4H, m), 4.43 (1H, t, J=5.3 Hz), 3.55 (2H, s), 3.28 (2H, t, J=5.8 Hz), 2.84 (2H, d, J=10.8 Hz), 1.96 (2H, t, J=11.3 Hz), 1.66 (2H, d, J=12.6 Hz), 1.37 (1H, d, J=10.8 Hz), 1.25-1.12 (2H, m). LC/MS (Method C): 512 (M+H)+. HPLC (Method E) Rt 2.16 min (Purity: 99.2%).

Provenance & Evidence