4-Hydroxypyrrolidine → HCID 59604167, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example 94, but starting from 4-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde, obtained as described in Example 113, Step 1, (100 mg; 0.24 mmol) and 3-pyrrolidinol (42.3 mg; 0.48 mmol) to give Example 142 as a white solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.76-8.73 (2H, m), 7.97-7.87 (3H, m), 7.76-7.69 (1H, m), 7.62-7.59 (2H, m), 7.56-7.47 (4H, m), 4.73 (1H, d, J=4.5 Hz), 4.26-4.20 (1H, m), 3.72-3.61 (2H, m), 2.73 (1H, dd, J=9.7, 6.2 Hz), 2.63 (1H, q, J=7.8 Hz), 2.49-2.46 (1H, m), 2.36 (1H, dd, J=9.5, 3.7 Hz), 2.09-1.99 (1H, m), 1.63-1.55 (1H, m). LC/MS (Method C): 484 (M+H)+. HPLC (Method E) Rt 2.13 min (Purity: 99.9%).

Provenance & Evidence