2-Methoxyethylamine → HCID 59604066, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example 94, starting from 3-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde (100 mg; 0.24 mmol) and 2-methoxyethanamine (36.4 mg; 0.48 mmol) to give Example 147 as a yellow solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.75 (2H, dd, J=4.62, 1.58 Hz), 8.05 (1H, s), 7.95-7.85 (2H, m), 7.76-7.69 (1H, m), 7.64-7.49 (6H, m), 3.90 (2H, s), 3.47 (2H, t, J=5.6 Hz), 3.29 (3H, s), 2.76 (2H, t, J=5.6 Hz). LC/MS (Method C): 472 (M+H)+. HPLC (Method E) Rt 2.18 min (Purity: 94.9%).

Provenance & Evidence