HCID 68649047, compound → HCID 59604051, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example 156, but using 1-(6-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)ethanone, obtained in Step 1, (101 mg; 0.22 mmol). The solvent was removed in vacuo to afford a purple oil which was dissolved in HCl (1 M, 1 mL) and MeOH (1 mL). The solution was passed through an SCX column eluting with MeOH (50 mL) followed by NH3 (1 M in MeOH, 50 mL). The solvent was removed in vacuo from the fractions containing product to afford Example 157 as a yellow solid. 1H NMR: (DMSO-d5, 400 MHz) δ 8.74 (2H, d, J=5.2 Hz), 7.90 (1H, t, J=7.7 Hz), 7.77-7.68 (1H, m), 7.60 (2H, d, J=5.2 Hz), 7.55-7.41 (2H, m), 7.24-7.15 (2H, m), 7.10-6.95 (1H, m), 5.89 (1H, s), 3.56-3.44 (2H, m), 3.01 (2H, t, J=8.6 Hz). LC/MS (Method C): 426 (M+H)+. HPLC (Method I) Rt 14.83 min (Purity: 95.2%).

Provenance & Evidence