反应详情

A solution of 1-benzylpiperazine (20.0 g, 0.114 mol) in acetonitrile (45 ml) was added to a solution of sulphuryl chloride (28 ml, 0.346 mol) in acetonitrile (50 ml) and the mixture heated under reflux for 17 hours, then cooled. The solvent was removed by evaporation under vacuum, then the residue triturated with ether (20×50 ml) to yield the title compound (27.8 g, 89%), which was used without further purification.

1. temperaturethe mixture heated
2. temperatureunder reflux for 17 hours
3. temperaturecooled
4. customThe solvent was removed by evaporation under vacuum
5. customthe residue triturated with ether (20×50 ml)