3-Fluoropyrrolidine → HCID 59604174, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example 94, but starting from 4-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde, obtained as described in Example 113, Step 1, (200 mg; 0.48 mmol) and (R)-3-fluoropyrrolidine (121 mg; 0.97 mmol) to give Example 167 as a white solid. 1H NMR: (CDCl3, 400 MHz) 8.72 (2H, dd, J=4.6, 1.6 Hz), 8.05 (2H, d, J=8.0 Hz), 7.63-7.52 (2H, m), 7.47 (2H, d, J=8.0 Hz), 7.40-7.33 (3H, m), 7.19 (1H, t, J=9.1 Hz), 5.25-5.11 (1H, m), 3.72 (2H, s), 2.92-2.69 (3H, m), 2.53-2.45 (1H, m), 2.24-1.99 (2H, m). LC/MS (Method C): 486 (M+HPLC (Method I) Rt 14.98 min (Purity: 95.7%).

Provenance & Evidence