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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2196014Generated: October 29, 2026

Potassium Hydroxide → HCID 25232992, compound

https://huagongshe.com/reaction/2196014

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant8-chloro-2-methyl-1H,2H,3H,4H,5H-pyrido(4,3-b)indoleHCID 19615—
Reactant3-Ethenyl-5-fluoropyridineHCID 57416843—
SolventN-methyl-2-pyrrolidoneHCID 13387—
ProductHCID 25232992HCID 25232992—

Reaction Steps

The title compound is prepared from a mixture of 8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole, 3-fluoro-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08338408B2
Source datasetuspto-grants-2012_12
ORD IDord-48dac3cf1800468a8d7b844813974be4
Source noteuspto-grants-2012_12