6-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amine → HCID 24964228, compound

HRID 2196118Notes

Reaction equation

HRID 2196118 reaction equation
Cl[C:2]1[C:3]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.Cl[C:20]1[CH:21]=[CH:22]C2N=C(N)N=C(N3C=NC=N3)C=2N=1>>[F:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[CH:9]=[CH:8][C:4]3[N:5]=[CH:6][N:7]=[C:2]([CH2:20][CH2:21][CH3:22])[C:3]=3[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 576983146-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amineHCID 579067564-Chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

Product 1

HCID 24964228HCID 24964228, compound

Procedure

The procedure of example 2 was repeated, except for the use of 4-chloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine (the synthesis of which has been disclosed in WO2006/135993) instead of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-yl-amine as a starting material. The resulting compound was characterised by its mass spectrum as follows: MS (m/z) 268.0 [M+H]+; HPLC Rt=5.13 minutes (Method A).

Workup

  1. customthe synthesis of which

Sources & evidence

ORD record
ord-44ef58f951fa4884b32052c8dd9b2742
Source dataset
uspto-grants-2012_12
Patent number
US08338435B2

Reaction notes

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