2,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine → HCID 57906750, compound

HRID 2196122Notes

Reaction equation

HRID 2196122 reaction equation
[CH3:1][Mg]Cl.[Cl:4][C:5]1[N:6]=[C:7](Cl)[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1>>[Cl:4][C:5]1[N:6]=[C:7]([CH3:1])[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 596478432,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidineHCID 178418332HCID 178418332, compound

Product 1

HCID 57906750HCID 57906750, compound

Procedure

The experimental procedure of example 5 was repeated, except for the use of methylmagnesium chloride instead of ethylmagnesium bromide and 2,4-dichloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine instead of N-[4-chloro-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-yl]-acetamide.

Sources & evidence

ORD record
ord-59157dbc38e540e18ca9bb0aa9f21c8d
Source dataset
uspto-grants-2012_12
Patent number
US08338435B2

Reaction notes

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