HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-cyclopropyl-4-iodopyridin-2(1H)-one → 1-cyclopropyl-4-iodopyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-cyclopropyl-4-iodopyridin-2(1H)-one | HCID 59190376 | — |
| Reactant | (S)-4-(2-hydroxy-2-methylpropyl)-4-phenyl-1-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-diazepan-2-one | HCID 59190387 | — |
| Product | 1-cyclopropyl-4-iodopyridin-2(1H)-one | HCID 59190376 | — |
| Product | (S)-1-((S)-1-(4-(1-cyclopropyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-4-(2-hydroxy-2-methylpropyl)-4-phenyl-1,3-diazepan-2-one | HCID 59190398 | — |
Reaction Steps
The title compound was prepared from (S)-4-(2-hydroxy-2-methylpropyl)-4-phenyl-1-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-diazepan-2-one and 1-cyclopropyl-4-iodopyridin-2(1H)-one following a procedure analogous to that described in Example 11 Step 2. 1-cyclopropyl-4-iodopyridin-2(1H)-one was prepared as described below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202857B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-6cfd763d94b543fba5c7c9ed4c591d06 |
| Source note | uspto-grants-2012_06 |