HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodo-1-methylpyridin-2(1H)-one → (S)-7-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-7-phenyl-1,3-oxazepan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodo-1-methylpyridin-2(1H)-one | HCID 53408009 | — |
| Reactant | (S)-7-(2-hydroxy-2-methylpropyl)-7-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazepan-2-one | HCID 59190368 | — |
| Product | (S)-7-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-7-phenyl-1,3-oxazepan-2-one | HCID 59190363 | — |
Reaction Steps
The title compound was prepared from (S)-7-(2-hydroxy-2-methylpropyl)-7-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazepan-2-one and 4-iodo-1-methylpyridin-2(1H)-one following a procedure analogous to that described in Example 18 Step 2. LC-MS Method 4 tR=1.11 min, m/z=497, 475, 457, 417.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202857B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-a26b054ecc114ecbb537932d35810ca3 |
| Source note | uspto-grants-2012_06 |