N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide → HCID 66666062, compound

Participants

Reaction Steps

To a solution of N-(2-(5-bromo-2-fluorophenyl)-4-(tert-butyldimethylsilyloxy)-3,3-difluorobutan-2-yl)-2-methylpropane-2-sulfinamide (8.8 g, 17.08 mmol) in dry MeOH (60 mL), dry HCl gas was purged for 30 min at −22° C. Reaction mixture was concentrated under reduced pressure and basified with NH4OH solution under cooling. Product was extracted with dichloromethane, washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to furnish title compound as a color less thick liquid. Yield=4.4 g (88%). TLC (50% ethyl acetate in Hexane): Rf=0.35),

Provenance & Evidence