Hydrochloric Acid → 2-Phenylpyrimidine-5-carboxylic acid

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Reaction Steps

A solution of 2-phenyl-pyrimidine-5-carboxylic acid methyl ester (3.15 g) and LiOH (0.71 g) in a mixture of MeOH, THF and water (1:1:1 in volume, 120 mL) is stirred at room temperature overnight. MeOH and THF are evaporated off to give an aqueous solution. The aqueous solution is acidified with 5% hydrochloric acid to adjust pH to between 2.5 and 3. The precipitate is filtered off and washed with water, dried in vacuo to yield 2.94 g (˜100%) of 2-phenyl-pyrimidine-5-carboxylic acid as a solid. MS: 201 (M+H).

Provenance & Evidence