HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-methoxy-N-methyl-2-(2-oxo-1-phenylethyl)benzamide → 6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-methoxy-N-methyl-2-(2-oxo-1-phenylethyl)benzamide | HCID 86610237 | — |
| Solvent | Phosphoric Acid | HCID 1004 | — |
| Product | 6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one | HCID 11254109 | — |
Reaction Steps
4-methoxy-N-methyl-2-(2-oxo-1-phenylethyl)benzamide (100 mg) was dissolved in 2 mL of phosphoric acid with gentle heating. After a solution was obtained, the reaction was partitioned between water and EtOAc. The organic solution was dried (Na2SO4) and concentrated. Flash chromatography (25% EtOAc in CH2Cl2) provided the titled compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338449B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c1df4f2a4fcf4335b8d19f301b6f76f6 |
| Source note | uspto-grants-2012_12 |