4-Fluorobenzaldehyde → 4-(4-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one

HRID 2196387Notes

Reaction equation

HRID 2196387 reaction equation
F[C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[C:11](=[O:20])[N:10]([CH3:21])[C:9]=2[CH3:22])[CH:5]=[CH:6][CH:7]=1.[F:23]C1C=CC(C=O)=CC=1>>[F:23][C:7]1[CH:6]=[CH:5][C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[C:11](=[O:20])[N:10]([CH3:21])[C:9]=2[CH3:22])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 680234-FluorobenzaldehydeHCID 117380444-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one

Product 1

HCID 112549694-(4-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one

Procedure

Following the procedure for 4-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one, using (in Step A) 4-fluorobenzaldehyde in place of 3-fluorobenzaldehyde, the title compound was synthesized.

Sources & evidence

ORD record
ord-1fc486372095469d925902edf506cfa3
Source dataset
uspto-grants-2012_12
Patent number
US08338449B2

Reaction notes

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