HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 3-tert-butyl-2-methyl-4-phenyl-6-(4-phenylbutoxy)isoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one | HCID 11278230 | — |
| Reactant | (4-Iodobutyl)benzene | HCID 12709818 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-tert-butyl-2-methyl-4-phenyl-6-(4-phenylbutoxy)isoquinolin-1(2H)-one | HCID 11316602 | — |
Reaction Steps
A solution of 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one (50 mg), 4-phenyl-1-iodobutane (100 mg) and cesium carbonate (100 mg) in DMF (2.5 mL) was heated at 80 C for 6 h. The reaction was partitioned between water and EtOAc. The organic solution was dried (Na2SO4) and concentrated, then purified by flash chromatography (20% EtOAc in hexanes) to give the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338449B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ecefeb6c2a434cebba8617c2056bd188 |
| Source note | uspto-grants-2012_12 |