HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphoric Acid → 2-ethyl-6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | 4-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one | HCID 11738044 | — |
| Reactant | 2-benzyl-N-ethyl-4-methoxybenzamide | HCID 68512662 | — |
| Product | 2-ethyl-6-methoxy-3-methyl-4-phenylisoquinolin-1(2H)-one | HCID 11150527 | — |
Reaction Steps
Following the procedure for 4-(3-fluorophenyl)-6-methoxy-2,3-dimethylisoquinolin-1(2H)-one (Step C), using 2-benzyl-N-ethyl-4-methoxybenzamide in place of 2-(3-fluorobenzyl)-4-methoxy-N-methylbenzamide and heating the final phosphoric acid solution to 100 C, the titled compound was synthesized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338449B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-4363c8c522c2471ea8496f8e2ed41f4f |
| Source note | uspto-grants-2012_12 |