Diisopropylethylamine → HCID 59355020, compound

Participants

Reaction Steps

To a solution of 5-bromo-2-pyridinecarboxylic acid (97 mg, 2.6 mmol), PyBrOP (269 mg, 0.578 mmol) and diisopropylethyl amine (419 uL, 2.41 mmol) in DCM (5 mL) at 25° C. was added 2-{(2S)-2-amino-3-[2-(trifluoromethyl)phenyl]propyl}-1H-isoindole-1,3(2H)-dione (168 mg, 0.481 mmol)[prepared in preparation 3]. After 16 h, the solution was partitioned between H2O and washed with DCM. The combined organic fraction were dried (Na2SO4), concentrated and used directly without further purification: LC-MS (ES) m/z=435 (M+H)+.

Provenance & Evidence