Diisopropylethylamine → HCID 59354995, compound

Participants

Reaction Steps

To a solution of 3-bromo-4-(1-methyl-1H-pyrazol-5-yl)benzoic acid (100 mg, 0.36 mmol), PyBrOP (277 mg, 0.59 mmol) and diisopropylethyl amine (0.11 mL, 0.59 mmol) in DCM (6 mL) at 25° C. was added 2-{(2S)-2-amino-3-[2-(trifluoromethyl)phenyl]propyl}-1H-isoindole-1,3(2H)-dione (161 mg, 0.36 mmol) [prepared according to Preparation 3]. After 16 h, the solution was concentrated and purified via column chromatography (silica, hexanes/EtOAc, 2:1) affording the title compound (172 mg, 78%) as a white solid: LC-MS (ES) m/z=612 (M+H)+.

Provenance & Evidence