Trifluoroacetic acid → HCID 25051481, compound

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Reaction Steps

1,1-dimethylethyl[3-{[3-(1-methyl-1H-pyrazol-5-yl)phenyl]amino}-3-oxo-2-(phenylmethyl)propyl]carbamate (170 mg, 0.39 mmol) was dissolved in DCM (10 mL) and treated with TFA (1 mL). After 1 h, the solution was concentrated and purified using reverse-phase HPLC (C18 column: H2O/CH3CN, 40-10%) affording the bis-TFA salt of the title compound (115 mg, 52%) as a white solid. LC-MS (ES) m/z=335 (M+H)+, 1H NMR (d4-MeOD, 400 MHz) δ 7.76 (br s, 1H), 7.43 (br s, 1 h), 7.35-7.23 (m, 9H), 4.55 (m, 1H), 3.72 (s, 3H), 3.23 (dd, J=3.5, 13.1 Hz, 1H), 3.13 (dd, J=10.4, 13.1 Hz, 1H), and 3.03-2.95 (m, 2H).

Provenance & Evidence