Diisopropylethylamine → HCID 59354988, compound

Participants

Reaction Steps

Hunig's base (0.084 ml, 0.48 mmol) was added to a suspension of 4-(1-methyl-1H-1,2,4-triazol-5-yl)benzoic acid (39.3 mg, 0.19 mmol), 2-{(2S)-2-amino-3-[2-(trifluoromethyl)phenyl]propyl}-1H-isoindole-1,3(2H)-dione (62 mg, 0.16 mmol), and PyBroP (75 mg, 0.16 mmol) in DCM (1 ml). The reaction mixture became clear and was stirred at RT overnight. The reaction mixture was loaded directly on a 25S Biotage column, which was eluted with 50-100% EA/DCM to give 67.3 mg of product. LC-MS (ES) m/z=534 (M+H)+.

Provenance & Evidence