Hydrochloric Acid → HCID 69809895, compound

Participants

Reaction Steps

121 mg of 6-(3-tert-butoxymethylphenyl)-2-pyridin-3-ylimidazo[1,2-a]pyridine are suspended in 5 ml of dichloromethane; 7.48 ml of a 0.1N solution of hydrochloric acid in 2-propanol are added thereto, dropwise and with stirring, and the mixture is stirred at ambient temperature for 7 hours. The mixture is concentrated under reduced pressure. The solid obtained is triturated with diethyl ether, recovered by filtration and oven-dried under reduced pressure at 40° C. The solid is then dissolved at ambient temperature in a minimum of isopropanol and then reprecipitated using isopropyl ether. The precipitate formed (after 3 h in a refrigerator) is recovered by filtration, washed with pentane and then oven-dried under reduced pressure at 50° C. 60 mg of compound are obtained.

Provenance & Evidence