Potassium Phosphate, Tribasic → HCID 44230454, compound

Participants

Reaction Steps

In a screw reactor, 550 mg of [3-(2-chloroimidazo[1,2-a]pyridin-6-yl)phenyl]methanol, 550 mg of 3-quinolineboronic acid, 20 mg of palladium acetate, 70 mg of 2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl and 900 mg of K3PO4 are placed in 8 ml of anhydrous toluene. The reactor is closed and heating is carried out at 115° C. for 16 h. After cooling, the reaction mixture is filtered through celite and rinsed with dichloromethane. The organic phase is washed with a saturated solution of NaCl, and then separated, dried and concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. 90 mg of compound are obtained.

Provenance & Evidence