Potassium Phosphate, Tribasic → HCID 68639392, compound

Participants

Reaction Conditions

Reaction Steps

3 mg of palladium acetate, 11 mg of 2-(dicyclohexyl)phosphino-2′,6′-dimethoxy-1,1′-biphenyl, 270 mg of K3PO4, 110 mg of 3-furanboronic acid and a few drops of ethanol are placed in a reactor containing a mixture of 240 mg of 6-[2-[(tert-butyldimethylsilanyl)oxymethyl]phenyl]-2-chloroimidazo[1,2-a]pyridine in 2 ml of toluene degassed beforehand under an argon stream. The reactor is closed and heated at 115° C. for 16 h. After cooling, the reaction mixture is filtered through celite, washed with dichloromethane and then concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. 258 mg of compound are obtained.

Provenance & Evidence