HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → HCID 68638439, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Bromo-1-(thiophen-2-yl)propan-1-one | HCID 11769952 | — |
| Reactant | 5-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]pyridin-2-ylamine | HCID 44232378 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68638439 | HCID 68638439 | 67.2% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
In a glass tube, 280 mg of 5-[3-(tert-butyldimethylsilanyloxymethyl)phenyl]pyridin-2-ylamine, 390 mg of 2-bromo-1-thiophen-2-ylpropan-1-one and 190 mg of sodium hydrogencarbonate are dissolved in 5 ml of ethanol. The tube is closed and heated at 100° C. for 20 h. After cooling, the mixture is concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a heptane/ethyl acetate mixture. 260 mg of compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338451B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-74952a896aff4453826db99d96a0be16 |
| Source note | uspto-grants-2012_12 |