HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2196485Generated: October 31, 2026
Potassium Carbonate → 1-[3-(Tert-butyldimethylsilyloxy)propoxy]-5-methylpyrazole-3-carboxylic acid ethyl ester
https://huagongshe.com/reaction/2196485
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 5-methyl-1H-pyrazole-3-carboxylate | HCID 77645 | — |
| Reactant | (3-Bromopropoxy)(tert-butyl)dimethylsilane | HCID 607486 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[3-(Tert-butyldimethylsilyloxy)propoxy]-5-methylpyrazole-3-carboxylic acid ethyl ester | HCID 67113706 | — |
Reaction Steps
To a solution of 1.96 g of 5-methylpyrazole-3-carboxylic acid ethyl ester in 40 ml of DMF, 2.64 g of potassium carbonate and 3.53 ml of 3-(tert-butyldimethylsilyloxy)propylbromide were added, and the mixture was stirred at 50° C. for 18 hours. The solvent was evaporated, EtOAc was added to the residue, and the organic layer was washed with water and brine and dried over sodium sulfate. After the evaporation of the solvent, the obtained residue was purified by silica gel column chromatography (eluent:hexane-EtOAc=15:1˜5:1) to obtain 1.39 g of 1-[3-(tert-butyldimethylsilyloxy)propoxy]-5-methylpyrazole-3-carboxylic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08338429B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-899736e0661e457288d24e20882c414b |
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| Source note | uspto-grants-2012_12 |
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