Sodium Hydroxide → HCID 16665310, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-methyl-2-[(2-phenyl-pyrimidin-5-carbonyl)-amino]-thiazole-5-carboxylic acid ethyl ester (0.15 mmol) and 10% aqueous NaOH solution (4 mL) in THF (10 mL) is stirred at 60° C. for 18 hours. THF is evaporated and the residue is acidified with 5% hydrochloric acid to pH ˜2.0-2.5. The precipitate is filtered and dried to afford 4-methyl-2-[(2-phenyl-pyrimidin-5-carbonyl)-amino]-thiazole-5-carboxylic acid as a solid. MS: 341 (M+H).

Provenance & Evidence