4-(5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)thiophene-2-carbonitrile → HCID 59843210, compound

HRID 2196511Notes

Reaction equation

HRID 2196511 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1N(C2C=C(C#N)SC=2)N=[C:8]([C:18]([F:21])([F:20])[F:19])[CH:7]=1.[Cl-].[C:23]([C:25]1[S:29][C:28]([NH2+:30][NH2:31])=[CH:27][CH:26]=1)#[N:24]>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:30]([C:28]2[S:29][C:25]([C:23]#[N:24])=[CH:26][CH:27]=2)[N:31]=[C:8]([C:18]([F:19])([F:20])[F:21])[CH:7]=1

Participants

3

Reactant 2

HCID 598432044-(5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)thiophene-2-carbonitrileHCID 69090430HCID 69090430, compound

Product 1

HCID 59843210HCID 59843210, compoundYield 37%

Procedure

Following the same procedure as described for compound 14 (step 4, scheme 2, example 1c) except using 21 (278 mg, 1.58 mmol) instead of 13 to afford 22 (182 mg, 37%) as a beige solid. LRMS (ESI): calc. 309.1; found 310.1 (MH)+.

Sources & evidence

ORD record
ord-319d1fe9e0a847b9bce8789647a30ce8
Source dataset
uspto-grants-2012_12
Patent number
US08338437B2

Reaction notes

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