反应详情

Following procedures similar to those of Example 8 but substituting 4-amino-benzenesulfonamide (0.3 mmol) for 2,2-dioxo-2,3-dihydro-1H-2lamda*6*-benzo[c]isothiazol-5-ylamine, there is prepared 2-phenyl-pyrimidine-5-carboxylic acid (4-sulfamoyl-phenyl-amide as a solid. MS: 355 (M+H). IC50=5 nM.