2-Phenylpyrimidine-5-carboxylic acid → HCID 16665392, compound

HRID 219652Notes

Reaction equation

HRID 219652 reaction equation
N1SC=C2C=C(N)C=CC=12.[C:11]1([C:17]2[N:22]=[CH:21][C:20]([C:23]([OH:25])=O)=[CH:19][N:18]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[S:26]([C:30]1[CH:35]=[CH:34][C:33]([NH-:36])=[CH:32][CH:31]=1)(=[O:29])(=[O:28])[NH2:27]>>[S:26]([C:30]1[CH:31]=[CH:32][C:33]([NH:36][C:23]([C:20]2[CH:21]=[N:22][C:17]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)=[N:18][CH:19]=2)=[O:25])=[CH:34][CH:35]=1)(=[O:28])(=[O:29])[NH2:27]

Participants

4

Reactant 3

HCID 7473892-Phenylpyrimidine-5-carboxylic acidHCID 534226912,1-Benzothiazol-5-amineHCID 86623217HCID 86623217, compound

Product 1

HCID 16665392HCID 16665392, compound

Procedure

Following procedures similar to those of Example 8 but substituting 4-amino-benzenesulfonamide (0.3 mmol) for 2,2-dioxo-2,3-dihydro-1H-2lamda*6*-benzo[c]isothiazol-5-ylamine, there is prepared 2-phenyl-pyrimidine-5-carboxylic acid (4-sulfamoyl-phenyl-amide as a solid. MS: 355 (M+H). IC50=5 nM.

Sources & evidence

ORD record
ord-297ca5759a73449d94b4d5b1083144fc
Source dataset
uspto-grants-2012_06
Patent number
US08202863B2

Reaction notes

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