Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Methoxybenzylamine | HCID 81292 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 69300585 | HCID 69300585 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59843206 | HCID 59843206 | 59% |
Reaction Steps
To a stirred solution of 49 (38 mg, 0.083 mmol) in CH2Cl2 (0.83 mL) were added triethylamine (0.025 mL, 0.183 mmol) and BOP (44.1 mg, 0.100 mmol) followed by 2-methoxybenzylamine (0.013 mL, 0.100 mmol). The resulting solution was allowed to stir at 21° C. overnight and evaporated to dryness. The residue was purified via ISCO flash chromatography (40% to 100% EtOAc/hexanes; 12G column). The title product 50 (28 mg, 59% yield) was isolated as a pale yellow oil. LRMS (ESI): calc. 576.6; found 577.6 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08338437B2 |
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| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-be426b4d420c492fbef5218310bafaf9 |
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| Source note | uspto-grants-2012_12 |
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