Trifluoroacetic acid → HCID 59843177, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 57 (900 mg, 1.784 mmol) in CH2Cl2 (3.4 mL) was added TFA (2.8 mL, 35.7 mmol). The mixture was allowed to stir at 21° C. for 2 h. A saturated NaHCO3 aqueous solution was added and followed by extractions with CH2Cl2. It was then dried over Na2SO4 and evaporated. The crude was used without any further purification. The title product 58 (925 mg, 100% yield) was isolated as a beige powder. LRMS (ESI): calc. 404.4; found 405.6 (MH)+.

Provenance & Evidence