反应详情

温度

70 °C

To a stirred solution of 109 (4 g, 8.38 mmol) in EtOH (42 ml) was added trifluoroacetaldehyde hydrate (0.648 ml, 8.38 mmol) and the resulting solution was allowed to stir for 3 h at 70° C. The solvent was evaporated and AcOEt was added to the residue and the organic layer was washed with 1N HCl then with brine, dried over MgSO4, filtrated and concentrated. Crude 110 was obtained as yellow oil and was used as is for the next step. LRMS (ESI): calc. 329.3; found 330.2 (MH)+.

1. customThe solvent was evaporated
2. additionAcOEt was added to the residue
3. washthe organic layer was washed with 1N HCl
4. dry with materialwith brine, dried over MgSO4
5. filtrationfiltrated
6. concentrationconcentrated
7. customCrude 110 was obtained as yellow oil