HCID 59843189, compound → HCID 59843266, compound

HRID 2196562Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:40]=[CH:39][CH:38]=[CH:37][C:4]=1[CH2:5][NH:6][C:7]([C:9]1[N:13]([C:14]2[CH:15]=[C:16]([CH:30]=[CH:31][CH:32]=2)[CH2:17][N:18]([CH3:29])[CH2:19][CH2:20][NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[N:12]=[C:11]([C:33]([F:36])([F:35])[F:34])[CH:10]=1)=[O:8].[CH3:41]OC1C=CC=CC=1CNC(C1N(C2C=C(C=CC=2)CNCCN(C)C(=O)OC(C)(C)C)N=C(C(F)(F)F)C=1)=O.COC1C=CC=CC=1CNC(C1N(C2C=CC=C(CNC)C=2)N=C(C(F)(F)F)C=1)=O>>[CH3:1][O:2][C:3]1[CH:40]=[CH:39][CH:38]=[CH:37][C:4]=1[CH2:5][NH:6][C:7]([C:9]1[N:13]([C:14]2[CH:15]=[C:16]([CH:30]=[CH:31][CH:32]=2)[CH2:17][N:18]([CH3:29])[CH2:19][CH2:20][N:21]([CH3:41])[C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:25])[CH3:26])[N:12]=[C:11]([C:33]([F:35])([F:34])[F:36])[CH:10]=1)=[O:8]

Participants

Reactant 3

HCID 59843189HCID 59843189, compound

HCID 59843199HCID 59843199, compound

HCID 59843223HCID 59843223, compound

Product 1

HCID 59843266HCID 59843266, compound

Procedure

The title compound 142 (103 mg, 0.179 mmol, 46% yield) was isolated as white foam following the procedure described for the synthesis of compound 59 (scheme 8, example 6, step 7), except using 141 (205 mg, 0.3855 mmol) in place of 58. LRMS (ESI): (calc.) 575.6; (found) 576.5 (MH)+.

Sources & evidence

ORD record: ord-09f44f0834bf47fc8ae34d4740bb864b
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338437B2

Reaction notes

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