2-Methoxybenzylamine → HCID 69299483, compound

HRID 2196578Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]([CH2:20][C:21]1[S:25][CH:24]=[C:23]([N:26]2[C:30]([C:31]([OH:33])=O)=[CH:29][C:28]([C:34]([F:37])([F:36])[F:35])=[N:27]2)[CH:22]=1)[CH2:9][CH2:10][N:11]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH3:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:38][O:39][C:40]1[CH:47]=[CH:46][CH:45]=[CH:44][C:41]=1[CH2:42][NH2:43]>>[C:16]([O:15][C:13]([N:11]([CH3:12])[CH2:10][CH2:9][N:8]([CH2:20][C:21]1[S:25][CH:24]=[C:23]([N:26]2[C:30]([C:31](=[O:33])[NH:43][CH2:42][C:41]3[CH:44]=[CH:45][CH:46]=[CH:47][C:40]=3[O:39][CH3:38])=[CH:29][C:28]([C:34]([F:35])([F:36])[F:37])=[N:27]2)[CH:22]=1)[C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:14])([CH3:18])([CH3:19])[CH3:17]

Participants

Reactant 2

HCID 812922-Methoxybenzylamine

HCID 59843296HCID 59843296, compound

Product 1

HCID 69299483HCID 69299483, compound

Procedure

The titled compound 214 (140 mg, 38%) was obtained as a white crusty solid after following the method described to obtain compound 15a (scheme 2, example 1c, step 8) by using 212 (0.300 g, 0.547 mmol) and 2-methoxybenzylamine (75 mg, 0.547 mmol). LRMS(ESI): (calc.) 667.2 (found) 690.4 (MNa)+.

Sources & evidence

ORD record: ord-5e6e5af39250456082cdffbf33d2db47
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338437B2

Reaction notes

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