Hydrochloric Acid → HCID 59843324, compound

Participants

Reaction Steps

Compound 223 (45 mg, 0.094 mmol) was stirred in a saturated solution of HCl in DCM (1 mL) for 1.5 hours. The reaction was taken to dryness under high vacuum to give 224 (45.5 mg, tris-HCl salt) as a white solid. 1H NMR: (DMSO-d6) δ(ppm): 11.23 (br s, 1H), 9.51 (br s, 2H), 8.74 (s, 1H), 8.69 (s, 1H), 8.22 (d, J=8.0 Hz, 1H), 7.71 (s, 1H), 7.52 (dt, J=1.6, 8.8 Hz, 1H), 7.27 (d, J=7.6 Hz, 1H), 7.17 (t, J=7.2 Hz, 1H), 3.98 (s, 3H), 3.75-3.72 (m, 2H), 3.54 (m, 4H), 3.24-3.16 (m, 2H), 3.05-2.99 (m, 1H), 2.69 (s, 3H), 2.60 (t, J=5.2 Hz, 3H), 2.19-2.05 (m, 4H). LRMS (ESI): (calc.) 378.2 (found) 379.4 (MH)+.

Provenance & Evidence