1-Pyrrolidinepropanol → 1-(3-Bromopropyl)pyrrolidine hydrobromide

HRID 2196608Notes

Reaction equation

HRID 2196608 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8]O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[BrH:10].C(O)(=O)C>>[BrH:10].[Br:10][CH2:8][CH2:7][CH2:6][N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2093421-PyrrolidinepropanolHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 201359201-(3-Bromopropyl)pyrrolidine hydrobromide

Conditions

Temperature
100 °C

Procedure

1.833 g of 3-pyrrolidin-1-ylpropan-1-ol was dissolved in 8.4 ml of 5.1 M hydrogen bromide/acetic acid solution, and stirred overnight at 100° C. The solvent was evaporated away, the resulting residue was suspended in ethyl acetate, and the formed solid was taken out through filtration, washed with ethyl acetate and dried under reduced pressure. The above process was repeated three times to obtain 2.92 g of the entitled compound as a white solid.

Workup

  1. customThe solvent was evaporated away
  2. filtrationthe formed solid was taken out through filtration
  3. washwashed with ethyl acetate
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-23a60ab6bda94f1ca94626cb86362f55
Source dataset
uspto-grants-2012_12
Patent number
US08338460B2

Reaction notes

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