4-(Methylthio)benzaldehyde → HCID 69055255, compound

Participants

Reaction Steps

3 g of methyl 4-aminobutyrate hydrochloride and 2.8 ml of triethylamine were added to a chloroform solution of 2 g of 4-(methylthio)benzaldehyde, and 8.4 g of sodium triacetoxyborohydride was added to it, and stirred overnight. Aqueous sodium hydrogencarbonate solution was added to it, extracted with chloroform, and the organic layer was washed with saturated saline water. This was dried with anhydrous sodium sulfate, the solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography to obtain 2.88 g of 1-[4-(methylthio)phenyl]pyrrolidin-2-one as a colorless oil.

Provenance & Evidence