Sodium Sulfite → HCID 59706251, compound

Participants

Reaction Conditions

Reaction Steps

At 0° C., 9.2 mg of m-chloroperbenzoic acid was added to a chloroform solution of 20 mg of 3-({4-[2-(dimethylamino)ethoxy]phenyl}thio)-N-(3-methyl-1,2,4-thiadiazol-5-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]pyridine-2-carboxamide obtained in Example 1, and stirred at 0° C. for 30 minutes. Aqueous sodium sulfite solution was added to it, extracted with chloroform, and the organic layer was dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the residue was purified through reversed-phase middle-pressure liquid chromatography [ODS-AS-360-CC (by YMC), mobile phase: water/acetonitrile/0.1% trifluoroacetic acid]. The solvent of the obtained fraction was evaporated away under reduced pressure to obtain 17.5 mg of the entitled compound as a yellow solid.

Provenance & Evidence