Hydrochloric Acid → HCID 47002560, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of C-(3-cyano-phenyl)-N-methyl-methanesulfonamide (42 mg, 0.2 mmol) in THF (4 mL) is added a solution of BH3−THF in THF (1 M, 1 mL). The mixture is sealed and heated in a microwave reactor at 100° C. for 120 seconds. The mixture is poured into 1 M HCl (20 mL), basified with 3 M NaOH to pH ˜10, extracted with DCM (2×50 mL), dried with Na2SO4, filtered, and concentrated in vacuo to afford C-(3-aminomethyl-phenyl)-N-methyl-methanesulfonamide, which is used directly in the next without further purification.

Provenance & Evidence